Uracil Derivatives and Related Compounds. III. 5-Amino-1, 3, 6-trialkyluracil Derivatives. (1).
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3-Nitro, 1-Amino Guanidine and 5-Hydrazino-1H-Tetrazole Derivatives as New Energetic Materials
The synthesis of 3-amino-1-nitroguanidine (3-ANQ) and 5-hydrazino tetrazole (5-HT) derivatives as new energetic materials are described. Reaction of 3-ANQ with triethyl orthoformate leads to the formation of 3-nitramino triazole while no reaction was observed whit 5-HT. Addition of NaN3 to a mixture of 3-ANQ and triethyl orthoformate, afforded 1-nitroguanidyl tetrazole in excelle...
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the synthesis of 3-amino-1-nitroguanidine (3-anq) and 5-hydrazino tetrazole (5-ht) derivatives as new energetic materials are described. reaction of 3-anq with triethyl orthoformate leads to the formation of 3-nitramino triazole while no reaction was observed whit 5-ht. addition of nan3 to a mixture of 3-anq and triethyl orthoformate, afforded 1-nitroguanidyl tetrazole in excellent yield. on th...
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The 5′-phosphate ester of 5-nitro-2′-deoxyuridine (7c) is a potent mechanism-based inhibitor of thymidylate synthase.2 Compound 7c3 and 1-(â-D-arabinofuranosyl)5-nitrouracil4 have antiviral activity, and certain O-nitro esters of pyrimidine5 and purine6 nucleosides also have biological activity. The 5′-O-nitro esters of pyrimidine nucleosides function as good substrates for 5′-modification via ...
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* corresponding author. e-mail: [email protected] Butyl-substituted 1-amino-3-oxocyclohexane-1-carboxylic acid derivatives have been prepared from 5,5-tethered dienes of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine in stereoselective synthesis. RCM reactions of the diene afforded a heterospirenone which was the substrate for the conjugated addition reaction with lithium dibutylcuprate. Hydrol...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1958
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.6.482